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Measure & monitor
mucosal healing changes over time

The first and only serum test to measure
mucosal healing status in Crohn's disease (CD) patients.
  • Comprehensive: Features a proprietary algorithm specific to mucosal healing and a unique combination of 13 biomarkers to evaluate multiple mucosal damage and repair processes, regardless of disease location
  • Quantitative: Every test report provides a single objective Mucosal Healing Index Score that is consistent with severity of disease (remission – mild to moderate – severe)* – Scores can be tracked over time to assess response to therapeutic management
  • Actionable: Provides valuable information beyond endoscopy, biopsy, or inflammatory biomarkers
  • Flexible: Can be used any time and during any type of treatment

Well-characterized serum samples (N = 748) from 396 adult CD patients were utilized for the development and validation of the Mucosal Healing Index algorithm.1-3

Samples were divided into training and validation sets, to provide a Mucosal Healing Index Score that ranges from 0 to 100, and biomarkers were mathematically modeled against endoscopic disease severity (CDEIS or Simple Endoscopic Score-CD [SES-CD]).


* In a study where 748 serum samples from 396 CD patients were divided into 2 cohorts: 335 samples from 278 patients were used to develop the Mucosal Healing Index (biomarker expression was modeled against endoscopic scoring CDEIS or SES-CD) and 412 samples from 118 CD patients were analyzed with endoscopic scoring for independent validation.1
Mucosal Healing Index Score
Mucosal Healing Index Scores Over Time

90% concordance rate with endoscopically visualized mucosal inflammation2

PROMETHEUS® Monitr™ Crohn's Disease Test Performance<sup>2</sup>,*

† In a study where 748 serum samples from 396 CD patients were retrospectively analyzed. Remission was defined as CDEIS < 3 and mild endoscopic disease was defined as CDEIS 3-8. Endoscopic evidence of active disease was defined as CDEIS ≥ 3. Specimens that fell within Mucosal Healing Index (MHI) range 41-49 had an observed 78% probability of active disease.

Helps you:

  • Establish a baseline measurement at initial presentation
  • Assess disease activity and response to therapeutic management
  • Optimize your treatment plan
  • Counsel patients about therapeutic management goals
  • Reinforce importance of patient compliance to continue therapy

References:
  1. Vermeire S, D'Haens G, Hale M, et al. A novel serum test to describe the mucosal healing state by disease location in Crohn's disease patients. Accepted for presentation at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.
  2. Kelly OB, Silverberg MS, Dulai PD, et al. Development and validation of a multi-marker serum test for the assessment of mucosal healing in Crohn's disease patients. Accepted for presentation at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.
  3. Data on file. Prometheus Laboratories, Inc.

Monitr is a laboratory-developed test that was developed and validated under Federal CLIA laboratory guidelines, and is performed exclusively by Prometheus Laboratories Inc.