TNF = tumor necrosis factor; IBD = inflammatory bowel disease.
* Based on the Personalising Anti-TNF Therapy in Crohn’s Disease (PANTS) clinical study, which included a discovery cohort of 1240 biologic-naïve patients with Crohn’s disease starting infliximab or adalimumab and a replication cohort of 178 patients with IBD. The PANTS study only included subjects of European descent, 40% of whom carry the risk allele. Immunogenicity was defined as an antidrug antibody concentration of ≥ 10 AU/mL, irrespective of drug level, at 1 or more time points.
†Based on a separate retrospective study of 262 IBD patients on infliximab therapy of which 40% identified as variant carriers.
‡According to HLADQA1*05>G genotype from a Cox proportional hazard model. Data were adjusted for age, sex, weight, infliximab dose, and coimmunosuppression with an immunomodulator (azathioprine or methotrexate). The 95% confidence intervals are represented by blue (HLADQA1*05 wild type) and red (HLADQA1*05 variant) shading.