SAN DIEGO, Feb. 17, 2022 /PRNewswire/ -- Prometheus Laboratories Inc. ("Prometheus"), a leader of precision healthcare, announced today the launch of PredictrPK IFX, a test that aids healthcare providers with biologic dose optimization through individualized pharmacokinetic modeling. The value of adaptive dosing has been demonstrated in recent clinical studies, and PredictrPK brings this advancement into routine clinical practice for the treatment of inflammatory bowel disease (IBD).
"PredictrPK is a revolutionary test that supports precision-guided dosing of biologics. I am very excited about incorporating the test into our IBD patient care protocols. By estimating a patient's future drug trough level, PredictrPK offers an opportunity for earlier adjustments to treatment strategies including dose escalation, dose de-escalation, changing the infusion interval, or deciding when a switch in therapy is needed," said Donald Lum, MD, FACG, Medical Director of Inflammatory Bowel Disease at The Oregon Clinic Gastroenterology East.
"In IBD, the approach to treat a patient must be tailored to the individual. Precise dosing and optimization improve therapeutic outcomes. In our early clinical trials in precision-guided dosing, individual clinical inputs were combined with week 14 trough levels and antidrug antibody status. Adaptive modeling recommended a dose or interval change in 96% of patients on IFX to maintain specified serum trough levels. Continuing with standard of care dosing was only recommended for 22% of patients. Our recent study data, demonstrates that IFX discontinuation and the development of antidrug antibodies can be reduced through early, proactive dose optimization," commented Marla Dubinsky, MD, Chief, Pediatric Gastroenterology and Nutrition, Icahn School of Medicine at Mount Sinai, and Co-Director of the Susan and Leonard Feinstein IBD Clinical Center at Mount Sinai Hospital in New York City. Dr. Dubinsky is an internationally recognized leader in pediatric gastroenterology and pioneer in personalized medicine for IBD patients. Dr. Dubinsky and colleagues recently published their findings from the first proactive infliximab optimization in Inflammatory Bowel Disease.